Table 2.
Unadjusted | Adjusted | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Mean T/S ratioa | Telomere length (base pairs) | Mean T/S ratioa | Telomere length (base pairs) | |||||||
Mean | 95% CI | Mean | 95% CI | P value | Mean | 95% CI | Mean | 95% CI | P value | |
BMI | ||||||||||
Normal weight (reference) | 1.10 | 1.07–1.13 | 5930 | 5851–6009 | 1.06 | 1.03–1.09 | 5829 | 5747–5911 | ||
Overweight | 1.05 | 1.02–1.09 | 5813 | 5729–5897 | 0.003 | 1.04 | 1.00–1.08 | 5790 | 5698–5883 | 0.22 |
Obesity | 1.04 | 1.01–1.07 | 5780 | 5701–5859 | <0.001 | 1.04 | 1.01–1.07 | 5777 | 5705–5850 | 0.07 |
Four-phenotype model classificationb | ||||||||||
LA-HM (reference) | 1.08 | 1.05–1.12 | 5902 | 5815–5990 | 1.05 | 1.01–1.09 | 5822 | 5724–5920 | ||
LA-LM | 1.04 | 1.01–1.07 | 5799 | 5728–5871 | 0.01 | 1.04 | 1.01–1.07 | 5798 | 5726–5870 | 0.61 |
HA-HM | 1.07 | 1.04–1.11 | 5870 | 5784–5957 | 0.32 | 1.06 | 1.02–1.10 | 5842 | 5738–5946 | 0.64 |
HA-LM (SO) | 1.04 | 1.00–1.07 | 5790 | 5708–5872 | 0.004 | 1.02 | 0.98–1.05 | 5735 | 5650–5820 | 0.05 |
TrFM/ASM classificationc | ||||||||||
<15th centile (reference) | 1.10 | 1.05–1.15 | 5937 | 5819–6054 | 1.07 | 1.02–1.12 | 5858 | 5736–5979 | ||
15–84th centile | 1.05 | 1.02–1.08 | 5829 | 5754–5903 | 0.01 | 1.04 | 1.01–1.07 | 5797 | 5721–5874 | 0.15 |
≥85th centile (SO) | 1.05 | 1.02–1.08 | 5818 | 5750–5885 | 0.02 | 1.03 | 0.99–1.07 | 5767 | 5678–5857 | 0.16 |
Significant results are highlighted in bold.
aThe mean telomere length, relative to the reference DNA, was calculated and expressed as the mean T/S ratio.
bLA is low adiposity, HA is high adiposity, LM is low muscle mass and HM is high muscle mass.
cTrFM is truncal fat mass, ASM is appendicular skeletal mass.