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. 2021 Oct 29;46(2):333–341. doi: 10.1038/s41366-021-01005-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Volcano plot illustrating 43 significantly upregulated miRNAs (red dots, top 5 miRNAs are annotated: miR-31-5p, miR-215-3p, miR-215-5p, miR-30a-5p and miR-204-5p) and 39 downregulated miRNAs (blue dots, top five are annotated: miR-1273f, miR-200b-5p, miR-1247-5p, miR-552-5p and miR-1247-3p) with fold change >1 (B) Heatmap of significantly up-regulated miRNAs, for which expression differed significantly between the obese individuals pre-RYGB and the non-obese Controls. C Heatmap of significantly downregulated miRNAs, for which expression differed significantly between the obese individuals pre-RYGB and the non-obese Controls. D IPA network of miRNAs for which expression differed by logFC >1 in the obese pre-RYGB and non-obese Controls and their predicted target molecules.