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. 2021 Oct 18;46(2):269–278. doi: 10.1038/s41366-021-00985-1

Fig. 4. Age-related changes in the miR-582 hepatic expression in the 8-week-old and 12-month-old offspring.

Fig. 4

Relative expressions of miR-582-3p and miR-582-5p in the liver of the offspring at eight weeks and 12 months of age (a) and relative mRNA expression of phosphodiesterase 4D in the liver of the offspring at 12 months of age (b). CC 8w: mother received control diet and offspring-fed control diet after weaning up to eight weeks of age; OC 8w: mother received obesogenic diet and offspring-fed control diet after weaning up to eight weeks of age. CC 12 m: mother received control diet and offspring-fed control diet after weaning up to 52 weeks of age; OC 12 m: mother received obesogenic diet and offspring-fed control diet after weaning up to 52 weeks of age. Values are presented as means ± SEM; CC 8w: n = 8 and OC 8w: n = 8; CC 12 m: n = 8–9 and OC 12 m: n = 9 animals from independent litters for each group. Data were analyzed by Mann–Whitney U test or two-way ANOVA. *p < 0.05 and ****p < 0.0001.