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. 2022 Jan 14;8:795848. doi: 10.3389/fnut.2021.795848

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Copyright © 2022 Wang, Nettleton, Gänzle and Reimer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of maternal consumption of aspartame and stevia on cecal microbiota in rat dams and their offspring. Principle coordinate analysis (PCoA) (A1, B1–B3) of rat cecal microbiota; litter effects in offspring (A2); shared metagenomic assembled genomes (A3) between 3-week-old offspring from the same litter (left) and from different litters (right); Dietary effects in dams (C1), 3-week-old offspring (C2), and 18-week-old offspring (C3). Each dot represents an individual cecal sample. Data with asterisk (*) represents a significant difference (p < 0.05). W3, week 3; W18, week 18; APM, aspartame; STV, stevia; WTR, water control.