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. 2022 Jan 14;8:795848. doi: 10.3389/fnut.2021.795848

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Copyright © 2022 Wang, Nettleton, Gänzle and Reimer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Connections between cecal microbiome alterations and host parameters in 3-week old offspring. The top 10 influenced genomes in cecal microbiota of 3-week-old offspring (ternary plot) and the relative abundance of 3 representative influenced genomes (boxplots) (A); mRNA expression fold change of jejunal/ileal lactase gene (lct) and GATA4 (gata4) (B); Growth peformance and body composition of weanlings (C); The coefficient matrix of Spearman's rank correlations between the most influenced genomes, metabolic enzymes, gene expression, and the corresponding growth and body composition of 3-week old offspring (D). Data with asterisk (*) represents significant difference (p < 0.05). APM, aspartame; STV, stevia; WTR, water control.