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. 2022 Jan 24;119(4):e2119078119. doi: 10.1073/pnas.2119078119

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Copyright © 2022 the Author(s). Published by PNAS.

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Fig. 5. — MeCP2 and TCF20 share common downstream neuronal genes and pathways. (A) Venn diagrams showing DEGs common to Tcf20^+/− and Mecp2^–/y mouse models; (Left) all DEGs; (Center) up-regulated DEGs; (Right) down-regulated DEGs (full lists of Tcf20^+/− and Mecp2^–/y DEGs are given in Datasets S2 and S3, respectively). The percentage rate indicates the ratio of the number of overlapped DEGs to the number of Tcf20^+/− DEGs. (B) Scatter plot showing log₂ fold-change for overlapped DEGs in Tcf20^+/− vs. Mecp2^–/y mouse models. Majority of the DEGs common to Tcf20^+/− and Mecp2^–/y mouse models changed in the same direction. (C) Coexpression networks of the down- (Left, blue) and up-regulated (Right, red) overlapped genes between Tcf20^+/− and Mecp2^–/y mouse models. Colored ellipses indicate the enriched gene ontology terms or pathways in each network. Node size is proportional to coexpression degree. Node color reflects log₂ fold-change in Tcf20^+/− mice.