Table 2.
Differences between the Mg and placebo groups at each study assessment estimated by linear mixed models
| Outcome | Beta coefficients (95% confidence intervals) | ||
|---|---|---|---|
| Group (Mg vs placebo) | Group*time (3 months) |
Group*time (6 months) |
|
| Magnesium |
0.0 ( − 0.0, 0.1) p = 0.46 |
0.0 ( − 0.0, 0.1) p = 0.42 |
0.0 ( − 0.0, 0.1) p = 0.78 |
| TNF-α |
−1.0 ( − 2.6, 0.7) p = 0.23 |
0.2 ( − 1.7, 2.0) p = 0.85 |
0.5 ( − 1.6, 2.7) p = 0.61 |
| C-reactive protein |
− 1.5 ( − 5.2, 2.2) p = 0.43 |
1.0 ( − 2.0, 4.1) p = 0.48 |
− 3.2 ( − 6.0, − 0.4) p = 0.03 |
| FEV1 |
− 0.1 ( − 0.2, − 0.0) p = 0.03 |
0.0 ( − 0.04, 0.04) p = 0.98 |
− 0.02 ( − 0.1, 0.03) p = 0.46 |
| FEV1/FVC |
− 4.2 ( − 11.0, 2.5) p = 0.21 |
0.7 ( − 2.9, 4.2) p = 0.71 |
− 1.0 ( − 3.8, 1.8) p = 0.47 |
| PEF |
− 1.0 ( − 1.9, − 0.1) p = 0.03 |
0.3 ( − 0.5, 1.0) p = 0.44 |
0.0 ( − 0.4, 0.5) p = 0.85 |
| Max handgrip |
2.1 ( − 3.9, 8.1) p = 0.49 |
− 1.9 ( − 4.4, 0.6) p = 0.13 |
− 1.1 ( − 3.4, 1.2) p = 0.34 |
| 6MWT |
− 41.8 ( − 88.9, 5.4) p = 0.08 |
− 2.8 ( − 45.2, 39.7) p = 0.90 |
24.8 ( − 29.0, 78.7) p = 0.35 |
| Flex peak torque |
− 4.3 ( − 10.9, 2.3) p = 0.20 |
3.9 ( − 3.4, 11.3) p = 0.29 |
− 1.7 ( − 8.1, 4.9) p = 0.61 |
| Ext peak torque |
− 7.0 ( − 19.6, 5.6) p = 0.27 |
3.8 ( − 5.9, 13.4) p = 0.43 |
3.4 ( − 5.5, 12.2) p = 0.45 |
| Isom M max |
− 5.7 ( − 22.6, 11.2) p = 0.50 |
− 1.3 ( − 15.2, 12.6) p = 0.85 |
7.8 ( − 5.0, 20.7) p = 0.23 |
| SGRQ total |
− 11.1 ( − 19.0, − 3.2) p = 0.01 |
2.2 ( − 4.5, 8.9) p = 0.52 |
0.3 ( − 5.8, 6.4) p = 0.91 |
| SGRQ activities |
− 15.9 ( − 28.4, − 3.5) p = 0.01 |
3.8 ( − 8.8, 16.5) p = 0.55 |
7.8 ( − 2.7, 18.4) p = 0.14 |
| SGRQ impact |
− 7.3 ( − 15.5, 0.9) p = 0.08 |
0.6 ( − 6.1, 7.2) p = 0.87 |
− 2.7 ( − 9.3, 3.9) p = 0.42 |
| SGRQ symptoms |
− 7.7 ( − 16.9, 1.6) p = 0.10 |
1.7 ( − 9.6, 13.1) p = 0.76 |
− 7.5 ( − 19.0, 4.0) p = 0.20 |
| EQ5D |
0.0 ( − 0.1, 1.8) p = 0.53 |
− 0.0 ( − 0.1, 0.6) p = 0.52 |
0.0 ( − 0.1, 0.1) p = 0.90 |
| EQ5D VAS |
7.0 ( − 2.8, 16.9) p = 0.16 |
− 2.9 ( − 11.5, 5.8) p = 0.51 |
3.8 ( − 5.0, 12.6) p = 0.39 |
| MRC |
− 0.1 ( − 0.6, 0.3) p = 0.56 |
− 0.1 ( − 0.5, 0.4) p = 0.72 |
− 0.3 ( − 0.9, 0.3) p = 0.36 |
Coefficients are derived from linear mixed models including group, time, and group*time, adjusted for SGRQ total (except when SGRQ scales are the outcomes); the intercept is set as random
TNF-α tumor necrosis factor-α, FEV1 predicted FEV1 (forced expiratory volume in one second), FEV1/FVC Tiffeneau index, PEF peak expiratory flow, Max handgrip maximum handgrip strength, 6MWT six-minute walk test, Flex peak torque maximum flexion moment, Ext peak torque maximum extension moment, Isom M max maximum isometric moment, EQ5D EuroQoL-5D, VAS visual analogue scale, MRC Modified British Medical Research Council Questionnaire, SGRQ St George’s Respiratory Questionnaire