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. 2022 Jan 27;7:13. doi: 10.1038/s41541-022-00430-y

Fig. 3. Study 1 immunogenicity and functional assessment of TMV-Junc, TMV-NPNAx5, FL-CSP in mice challenged at 4WP3.

Fig. 3

A Geometric mean ± 95% CI at 2WP3 against FL-CSP (FL), repeat peptide or junctional peptide and B Avidity at 2WP3 (defined as the molarity of NaSCN required to reduce OD to half maximal compared to PBS wash) against FL, NANPx6, and junctional peptide coat. Bars are geometric mean ± 95% CI. C Survival curves for mice challenged at 4WP3. D Mean ILSDA ± SEM from four experiments at 1:30, 1:100, and 1:300 using pooled serum dilutions from 2WP3. Inhibition was described as % reduction in 18s parasite RNA relative to the control wells. For ELISAs, statistical significance between groups was determined by one-way ANOVA followed by Tukey’s correction; **** (p < 0.0001), ** (p < 0.01), or * (p < 0.05).