Table 2.

Hantzsch synthesis of polyhydroquinoline derivatives in the presence of Zn-MOF in PEG-400 at 80 °C.

Entry	Aryl aldehyde	Product	Time (min)	Yield (%)a,b	Melting point
					Measured	Literature
1			150	83	216–218	217–21950
2			85	96	237–240	234–23750
3			120	74	252–255	252–25551
4			70	58	247–250	245–24751
5			180	69	201–204	203–20450
6			150	79	263–265	246–24850
7			75	95	173–175	176–17850
8			90	85	217–219	216–21850
9			90	97	217–219	216–21850
10			150	92	227–229	231–23351
11			90	91	301–303	303–30550

^aIsolated yields.

^bReaction conditions: Aromatic aldehyde (1 mmol), dimedone (1 mmol), ethyl acetoacetate (1 mmol), ammonium acetate (1.2 mmol), Zn-MOF (10 mg) and PEG-400 (2 mL) at 80 °C.

^cReaction conditions: Aromatic aldehyde (1 mmol), dimedone (2 mmol), ethyl acetoacetate (2 mmol), ammonium acetate (2.4 mmol), Zn-MOF (20 mg) and PEG-400 ( 4 mL) at 80 °C.