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. 2022 Jan 27;12:1459. doi: 10.1038/s41598-022-05408-3

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment of SCI with TUDCA reduces expression of inflammatory genes. At 4 dpo, RNA extracts from spinal cord were analyzed with quantitative RT-PCR. ANOVA revealed significant treatment effects on the transcription of (a) IL-6 [F (2, 12) = 8.3, p < 0.01, (b) IL-12β [F (2, 12) = 1.6, n.s.]; (c) IFNβ [F (2, 12) = 3.9, p < 0.05], and (d) HMGB1 [F (2, 12) = 4.5, p < 0.05]; post hoc Dunnett's tests: * comparison SCI vs. control; # SCI vs SCI-TUDCA; n = 5 rats). Treatments conditions are indicated as sham: laminectomy only; SCI: SCI with two i.p. injections of saline; SCI-TUDCA: SCI with two injections of 300 mg/kg TUDCA at the time of surgery and 24 h later.