Table 2.
Characteristics of minor ischemic stroke patients presenting with (n = 23) or without large vessel occlusion (LVO; n = 557).
| Patients without LVO (N = 559) | Patients with LVO (N = 23) | P Value | |
|---|---|---|---|
| Age mean ± SD, y | 73.4 ± 16.3 | 70.1 ± 17.8 | 0.287 |
| Age median (IQR), y | 78 (64–86) | 72 (5–84) | |
| Male, n (%) | 277 (49.6) | 12 (52.2) | 0.805 |
| Hypertension, n (%) | 389 (69.6) | 14 (60.9) | 0.375 |
| Diabetes mellitus, n (%) | 115 (20.6) | 3 (13.0) | 0.377 |
| Hypercholesterolemia, n (%) | 208 (37.4) | 4 (17.4) | 0.051 |
| Current smoking, n (%) | 0.361 | ||
| Yes | 85 (15.3) | 3 (12.0) | |
| No | 430 (76.8) | 19 (84.0) | |
| Unknown | 44 (7.9) | 1 (4.0) | |
| History of AF, n (%) | 119 (21.4) | 10 (43.5) | 0.012 |
| Current alcohol consumption, n (%) | 33 (6.3) | 0 (0.0) | 0.226 |
| Coronary heart disease, n (%) | 72 (13.0) | 3 (13.0) | 0.997 |
| Chronic heart failure, n (%) | 40 (7.3) | 0 (0.0) | 0.179 |
| Peripheral artery disease, n (%) | 39 (7.0) | 1 (4.4) | 0.618 |
| Active cancer, n (%) | 18 (3.3) | 2 (8.7) | 0.168 |
| Previous TIA, n (%) | 80 (14.3) | 5 (21.7) | 0.323 |
| Previous stroke, n (%) | 111 (19.9) | 6 (27.3) | 0.395 |
| Prestroke treatments, n (%) | |||
| Antiplatelets agents | 185 (33.3) | 8 (34.8) | 0.885 |
| Anticoagulants | 84 (15.1) | 3 (13.0) | 0.783 |
| Antihypertensive treatment | 353 (63.6) | 12 (52.2) | 0.266 |
| Statins | 142 (25.6) | 2 (8.7) | 0.066 |
| NIHSS score at onset, median (IQR) | 2 (1–3) | 3 (2–5) | 0.001 |
| Prestroke cognitive status, n (%) | 0.567 | ||
| No cognitive impairment | 448 (80.3) | 19 (82.6) | |
| MCI | 58 (10.4) | 1 (4.4) | |
| Dementia | 52 (9.3) | 3 (13.0) | |
| Premorbid mRS score>2, n (%) | 117 (20.9) | 5 (21.7) | 0.926 |
| Living in an institution, n (%) | 41 (7.4) | 0 (0.0) | 0.177 |
| TOAST classification, n (%) | 0.011 | ||
| LAA | 60 (10.7) | 1 (4.4) | |
| CE | 130 (23.3) | 13 (56.5) | |
| SVD | 52 (9.3) | 0 (0.0) | |
| Other | 42 (7.5) | 1 (4.4) | |
| Undetermined | 247 (44.2) | 8 (34.8) | |
| Multiple causes | 28 (5.0) | 0 (0.0) |
AF, indicates atrial fibrillation; CE, cardioembolic; IQR, interquartile range; IV, intravenous; LAA, large artery atheroma; MCI, mild cognitive impairment; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; SVD, Small Vessel Disease; TIA, Transient Ischemic Attack; and TOAST, Trial of ORG 10172 in Acute Stroke Treatment.