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. 2022 Jan 27;5:98. doi: 10.1038/s42003-022-03037-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Physiological model of CNS during SILK study, incorporating fluid flows, ISF and CSF compartment volumes, and Michaelis–Menten kinetics for Aβ production. a Model structure. b Flows in the spinal SAS due to hourly CSF withdrawal. The volume of the lumbar SAS decreases when the CSF withdrawal rate Q_LP exceeds the CSF production rate (Q_CSF) and subsequently refills with CSF to its original volume. c Timeline of hourly CSF withdrawal. d Net flow in the spinal SAS. e Bidirectional flow in the spinal SAS.