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Production rates in presenilin mutation carriers and age-matched non-carriers.
| Mutation-carrier mean (S.E.) N = 9 | Sibling non-carriers mean (S.E.) N = 10 | P valuea | |
|---|---|---|---|
| Age | 45 (4) | 49 (5) | 0.61 |
| kf (ng/h) | 8000 (1000) | 8000 (1000) | 0.99 |
| Vmax,γ42 (μg/(mL h)) | 1.6 (0.2) | 0.80 (0.05) | 0.0079 |
| Vmax,γ42/ Vmax,γ38 | 160 (20) | 85 (3) | 0.0014 |
| Total gray volume (mL) | 600 (20) | 640 (10) | 0.14 |
at test; values in italics signify P < 0.05; values in bold italic signify: P < 0.01.
