Table 2.

Physiochemical parameters of selected SARS-CoV-2 M^pro proposed inhibitors from mushrooms.

Parameters	M_78	M_82	M_83	M_88	M_111	M_112	M_201	M_366	M_421	M_505
MW	410.37	399.28	414.32	439.35	458.46	340.33	382.32	366.32	540.60	554.63
Acceptable Range	≤ 500	≤ 500	≤ 500	≤ 500	≤ 500	≤ 500	≤ 500	≤ 500	≤ 500	≤ 500
NHBA	8	10	10	10	7	6	8	7	9	9
Acceptable Range	≤ 10	≤ 10	≤ 10	≤ 10	≤ 10	≤ 10	≤ 10	≤ 10	≤ 10	≤ 10
NHBD	4	4	4	4	4	5	5	4	4	3
Acceptable Range	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5
MR	108.40	95.81	102.07	110.38	127.88	93.92	100.77	98.75	136.97	141.70
Acceptable Range	40–130	40–130	40–130	40–130	40–130	40–130	40–130	40–130	40–130	40–130
iLOGp	2.39	1.48	2.37	2.26	2.72	2.15	1.74	1.83	3.811	2.93
Acceptable Range	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5	≤ 5

The parameters MW molecular weight, NHBA number of H-bond acceptors, NHBA number of H-bond donors, MR molar refractivity, iLOGp n-Octanol/Water partition coefficient).