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. 2022 Jan 27;12:1513. doi: 10.1038/s41598-022-05405-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of HOTAIR-interacting proteins by RNA-BioID. (A) Schematic overview of RNA-BioID. (B) Volcano plot showing the potential protein interactors of HOTAIR by RNA-BioID (FDR 0.05; s0 0.1). MRPLs are highlighted in blue, PRC2 complex members are highlighted in red, LSD1-CoREST members are highlighted in green. InterPro domains overrepresented in the data set (C). GO analysis showing Molecular Function (D), Cellular Component (E), and Biological Process (F). GO was performed with David 6.8., the four most significant terms are shown. The vertical dashed line represents the 0.05 cutoff used for the adjusted p-value. Number of significant proteins identified and the size of each annotation is shown next to each histogram. MCP MS2 coat protein, RBP RNA-binding domain, LFQ label free quantification.