Fig. 5.

Broad and potent neutralization by Multabody v2 against extended HIV-1 PsV panels. (A) Breadth and median IC₅₀ values (micrograms per milliliter) of T-01 Multabody versions (different shades of red diamond), individual IgGs (black circles), and IgG mixture (blue triangle) against a 25-PsV panel with 56% of PsV variants resistant to PGDM1400 neutralization. (B) Individual IC₅₀ values (micrograms per milliliter) for each PsV variant. IC₅₀ values in A and B were calculated from three biological replicates. (C) Potency (IC₅₀)-breadth (Left) and potency (IC₈₀)-breadth (Right) curve comparison of T-01 Multabody versions, as well as parental IgGs and an IgG mixture against an extended multiclade panel of 118 HIV-1 PsV variants. (D) Individual IC₅₀ (Left) and IC₈₀ (Right) values for each PsV variant in C. Yellow dots correspond to IC₅₀ values from PsVs that are highly resistant to PGDM1400 neutralization. The solid line in B and D denotes the median IC₅₀ neutralization titer of all viral strains in each panel.