Table 1.

The first 20 predictions, sorted according to the DCA mutability score, with the corresponding IEDB RF and the VOIs and VOIs in which the position has mutated

Position	AA Wuhan-Hu-1	DCA mutability score	IEDB RF (95% CI)	Pango lineage (ref. 38)
519	H	0.22	0.10 (0.08:0.14)
403	R	0.06	0.28 (0.24:0.32)
490	F	0.05	0.41 (0.38:0.45)
493	Q	0.04	0.43 (0.40:0.46)
372	A	0.01	0.39 (0.32:0.46)
501	N	−0.04	0.44 (0.40:0.47)	B.1.1.7; B.1.351; P.1; P.3
445	V	−0.06	0.18 (0.15:0.21)
498	Q	−0.11	0.24 (0.21:0.28)
441	L	−0.20	0.15 (0.12:0.19)
440	N	−0.21	0.10 (0.08:0.14)
484	E	−0.21	0.48 (0.45:0.51)	B.1.351; P.1; B.1.617; B.1.525; P.2; P.3
486	F	−0.21	0.43 (0.40:0.47)
443	S	−0.31	0.08 (0.05:0.11)
494	S	−0.32	0.38 (0.35:0.42)
483	V	−0.32	0.39 (0.36:0.43)	B.1.616
460	N	−0.37	0.16 (0.13:0.19)
444	K	−0.41	0.13 (0.10:0.16)
417	K	−0.43	0.44 (0.40:0.48)	B.1.351; P.1
439	N	−0.44	0.07 (0.04:0.10)
402	I	−0.50	0.08 (0.05:0.11)

Positions with IEDB RF above 0.3 are shown in bold.