Table 1.

Comparison of genotype and allele frequencies of the M132L single nucleotide polymorphism (SNP) in the prion protein gene (PRNP) between chronic wasting disease (CWD)-affected elks and matched healthy elks.

Authors	Year	Country		Total, n	Genotype frequencies, n			P-valuea	Allele frequencies, n		P-valueb	HWE
					MM	ML	LL		M	L
O'Rourke et al. (13)	1999	USA	CTL	344	230	102	12	0.0312	562	126	0.0084	0.8677
			CWD	43	37	6	0		80	6		0.6229
Perucchini et al. (16)	2008	USA	CTL	248	162	80	6	0.6927	404	92	0.4294	0.2872
			CWD	94	66	26	2		158	30		0.7621
In this study	2021	South Korea	CTL	204	144	49	11	0.9326	337	71	0.8000	0.0188
			CWD	49	35	12	2		82	16		0.4681

The number of genotype frequencies in each column indicates the number of genotypes. The number reported in each “Allele frequencies” column indicates the number of alleles. The number “Total, n” indicates the number of animals. Bold text indicates statistically significant results (P < 0.05). CTL, matched healthy elks; CWD, CWD-affected elk; HWE, Hardy-Weinberg equilibrium; P-value^a: Based on the comparison of genotype frequencies between healthy controls and CWD-affected animals; P-value^b: Based on the comparison of allele frequencies between healthy controls and CWD-affected animals.