Table 2.
Meta-analysis of the association between the M132L SNP of the PRNP gene and susceptibility to CWD.
| Genetic model | Association test | Heterogeneity | Publication bias | ||||
|---|---|---|---|---|---|---|---|
| Odds ratio | 95% confidence interval | P-value | Model | P-value | I 2 | Egger's test P-value | |
| Additive model (M vs. L) | 1.3325 | [0.9570; 1.8553] | 0.6246 | Fixed | 0.13 | 0.52 | 0.3852 |
| Recessive model (MM vs. ML+LL) | 1.3873 | [0.9546; 2.0161] | 0.6029 | Fixed | 0.15 | 0.48 | 0.4978 |
| Dominant model (MM+ML vs. LL) | 1.4120 | [0.4998; 3.9891] | 1 | Fixed | 0.82 | 0.00 | 0.1956 |
| Overdominant model (ML vs. MM+LL) | 0.7506 | [0.5113; 1.1019] | 1 | Fixed | 0.23 | 0.32 | 0.6099 |
| MM vs. LL | 1.4962 | [0.5266; 4.2505] | 1 | Fixed | 0.76 | 0.00 | 0.1181 |
| MM vs. ML | 1.3585 | [0.9238; 1.9978] | 0.8363 | Fixed | 0.21 | 0.37 | 0.5972 |
| ML vs. LL | 1.2004 | [0.4067; 3.5433] | 1 | Fixed | 0.94 | 0.00 | 0.6146 |