FIGURE 4.

Hepatic sinusoidal endothelial expression of FcγR2b alters in disease. Representative immunochemical (left panels, 10× original magnification Bar is 200 um) and immunofluorescent stains (right panels, 100× original magnification, Bar is 20 um) for FcγR2b on representative examples of healthy (top row) and diseased liver [bottom row, cirrhotic explanted liver from patient with PSC (left) or ALD (right)]. FcγR is localized to the LSEC in both cases, but expression is more intense and consistent across the sinusoid in a healthy context. In explanted cirrhotic human livers some areas of sinusoids lack expression completely.