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Molecular Interactions of PARP1 or TNK1 with gammaherpesviruses during latency. PARP1 modulates latent infection of gammaherpesviruses, EBV (A) or KSHV (B). In turn, LMP1 induces PARP1 activity, contributing to the tumorigenesis of EBV. (C) TNK1 (aka PARP5) downregulates the EBNA1-dependent OriP replication. The detailed mechanisms are explained in the text and summarized in Table 1.
