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Molecular Interactions between PARP1 and gammaherpesviruses during lytic replication. PARP1 regulates lytic replication of EBV (A), KSHV (B), or MHV-68 (C). The viruses also, in turn, modulate PARP1 via sequestering or degrading PARP1 to promote virus replication. The detailed mechanisms are explained in the text and summarized in Table 1.
