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. 2022 Jan 28;8:38. doi: 10.1038/s41420-022-00831-x

Fig. 7. Single-cell transcriptional analysis reveals the cell-cell crosstalk network in FHP.

Fig. 7

A Ligand activity prediction by NicheNet showing the top 20 ligands best predicting the entire DEGs in epithelial cells between FHP and control lungs. B The bubble plot showing expression patterns of the predicted ligands on macrophages, endothelial cells, fibroblasts, T cells, NK cells and monocytes. C Ligand–target matrix displaying the regulatory potential of predicted ligands on target genes from the epithelial cells in FHP lungs. D The top 20 ligands best predicting the entire DEGs in fibroblasts between FHP and normal lungs. E The bubble plot showing expression patterns of the predicted ligands on epithelial cells, macrophages, endothelial cells, T cells, NK cells, and monocytes. C Ligand–target matrix displaying the regulatory potential of predicted ligands on target genes from the fibroblasts in FHP lungs. G Schematic showing the inferred cell-cell interaction network during FHP.