TABLE 1.
Studies examining cardiorespiratory adjustments during normoxia or hypoxia in humans with high Hb-O2 affinity.
| Study | Age (years) | Sex (n) | Hb type | P50 (mmHg) | [Hb] (g/dL) | Hct (%) | Study design |
| Hebbel et al., 1977 | 12 | 1M | Hb Andrew-Minneapolis | 17 | 16 | NR | Hypoxic ventilatory response (FiO2 = 0.13, ∼3800 m) |
| 18 | 1F | Hb Andrew-Minneapolis | 17 | 17 | NR | ||
| Hebbel et al., 1978 | 12 | 1M | Hb Andrew-Minneapolis | 17 | 17 | 48 | High-altitude acclimatization (∼3100 m) and graded cycling to exhaustion |
| 18 | 1F | Hb Andrew-Minneapolis | 17 | 17 | 50 | ||
| Rossoff et al., 1980 | 25 | 2M | Hb Rainier | 12 | NR | NR | Hypoxic ventilatory response (FiO2 = 0.14, ∼3300 m) |
| Wranne et al., 1983 | 30 | 1M | NR | 14 | 19 | 55 | Normoxic submaximal cycling |
| 31 | 1M | NR | 14 | 18 | 54 | ||
| Länsimies et al., 1985 | 38 (14) | 5M | Hb Linköping | 16 (0.4) | 19 (1) | NR | Normoxic graded cycling to exhaustion |
| 32 (8) | 5F | Hb Linköping | 17 (0.5) | 16 (4) | NR | ||
| Dominelli et al., 2019 | 45 (8) | 3M | Hb Malmö | 15 (0.2) | 21 (1) | 63 (3) | Hypoxic ventilatory response (FiO2 = 0.14, ∼3300 m) |
| 43 (15) | 6F | Hb Malmö (n = 5), Hb San Diego (n = 1) | 16 (1.1) | 19 (1) | 55 (3) | ||
| Dominelli et al., 2020 | 45 (8) | 3M | Hb Malmö | 15 (0.2) | 21 (1) | 63 (3) | Normoxic and normobaric hypoxic (FiO2 = 0.15, ∼2600 m) graded cycling to exhaustion |
| 31 (9) | 8F | Hb Malmö (n = 7), Hb San Diego (n = 1) | 16 (0.9) | 18 (1) | 54 (2) | ||
The fraction of inspired O2 and associated elevation are provided under study design. Abbreviations: M, male; F, female; Hb, hemoglobin; P50, the PO2 at which 50% of hemoglobin is saturated with O2; Hb, hemoglobin; Hct, hematocrit; FiO2, fraction of inspired O2; NR, not reported. Numbers within parentheses throughout the table indicate standard deviations.