Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 14;9:759421. doi: 10.3389/fcell.2021.759421

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhang, Zhu, Zheng, Xie, Wang, Zou, Li, Li, Cai, Gu, Yao and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Possible mechanism for TGR5 alleviates DR by maintaining mitochondrial homeostasis. Figure 7 illustrated that TGR5 ameliorated DR by affecting mitochondrial dynamics, including inhibited mitochondrial fission and enhanced mitophagy in retinal endothelial cells. Specific regulatory mechanisms may be through regulating the PKCδ/Drp1-HK2-PINK1/Parkin signaling pathway. Our findings suggested that TGR5 may be a potential target for therapeutic intervention of DR.