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. 2022 Jan 14;9:787278. doi: 10.3389/fcell.2021.787278

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Copyright © 2022 Xie, Shi, Chen, Zhou, Luo, Hong, Tian, Wu, Zhou, Lin, Dou, Wu, Huang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apigenin (API) treatment alleviates TBHP-induced ECM degradation in NP cells. NP cells were treated with TBHP and various concentrations of API for 24 h. (A) The protein expression of collagen II, aggrecan, ADAMTS5, and MMP13 in NP cells as treated above were assessed by Western blot. (B) Quantification of collagen II, aggrecan, ADAMTS5, and MMP13 by immunoblot. (C) The cell immunofluorescence images of collagen II and MMP13 (scale bar: 20 μm). (D) Quantitative analysis of the fluorescence intensity of collagen II and MMP13 was done by ImageJ. Data are represented as mean ± SD. ****p < 0.0001, *p < 0.05.