. 2022 Jan 27;5(1):e2145446. doi: 10.1001/jamanetworkopen.2021.45446

Table 1. Summary and Analysis of DSN in Cycle 1.

Treatment group^a	Mean DSN	Noninferiority met^b
Pegfilgrastim^c	0.25 (0.21-0.29)	NA
Plinabulin^c	0.77 (0.68-0.86)	NA
Mean difference between treatment arms^d	0.52 (0.40-0.65)	Met

Abbreviations: DSN, duration of severe neutropenia; NA, not applicable.

^{^a}

The pegfilgrastim group received docetaxel, 75 mg/m², plus pegfilgrastim, 6 mg; the plinabulin group received docetaxel, 75 mg/m², plus plinabulin, 40 mg.

^{^b}

Defined as an upper confidence limit of less than 0.65.

^{^c}

Using 2-sided 95% CI with group sequential adjustment.

^{^d}

Using 2-sided 98.52% CI with group sequential adjustment.