Table 1. Clinical Characteristics of Entire Study Cohort Across Genetically Defined Racial Categories.
| Clinical characteristic | Patients, No./total No. (%) | P valueb | |||||||
|---|---|---|---|---|---|---|---|---|---|
| All | Genetically defined race and ethnicitya | ||||||||
| Black | East Asian | Hispanic | South Asian | White | Other-Asian | Other-US | |||
| Age at diagnosis, y | |||||||||
| <1 | 27/2428 (1.1) | 0/199 | 6/232 (2.6) | 2/520 (0.4) | 2/69 (2.9) | 7/1128 (0.6) | 7/162 (4.3) | 3/118 (2.5) | <.001 |
| ≥1 to <10 | 1704/2428 (70.2) | 131/199 (65.8) | 175/232 (75.4) | 333/520 (64.0) | 58/69 (84.1) | 790/1128 (70.0) | 137/162 (84.6) | 80/118 (67.8) | |
| ≥10 | 697/2428 (28.7) | 68/199 (34.2) | 51/232 (22.0) | 185/520 (35.6) | 9/69 (13.0) | 331/1128 (29.3) | 18/162 (11.1) | 35/118 (29.7) | |
| Sex | |||||||||
| Male | 1340/2318 (57.8) | 112/195 (57.4) | 146/230 (63.5) | 270/488 (55.3) | 42/68 (61.8) | 610/1065 (57.3) | 102/162 (63.0) | 58/110 (52.7) | .26 |
| Female | 978/2318 (42.2) | 83/195 (42.6) | 84/230 (36.5) | 218/488 (44.7) | 26/68 (38.2) | 455/1065 (42.7) | 60/162 (37.0) | 52/110 (47.3) | |
| Leukocyte count at diagnosis | |||||||||
| <50 000 cells/µL | 1646/2326 (70.8) | 132/195 (67.7) | 163/228 (71.5) | 365/494 (73.9) | 43/68 (63.2) | 753/1069 (70.4) | 116/161 (72.0) | 74/111 (66.7) | .40 |
| ≥50 000 cells/µL | 680/2326 (29.2) | 63/195 (32.3) | 65/228 (28.5) | 129/494 (26.1) | 25/68 (36.8) | 316/1069 (29.6) | 45/161 (28.0) | 37/111 (33.3) | |
| Study cohort | |||||||||
| COG | 814/2428 (33.5) | 52/199 (26.1) | 21/232 (9.1) | 215/520 (41.3) | 11/69 (15.9) | 455/1128 (40.3) | 3/162 (1.9) | 57/118 (48.3) | NA |
| Ma-Spore | 414/2428 (17.1) | NA | 202/232 (87.0) | NA | 50/69 (72.5) | 2/1128 (0.2) | 156/162 (96.3) | 4/118 (3.4) | NA |
| St Jude | 1012/2428 (41.7) | 147/199 (73.9) | 9/232 (3.9) | 117/520 (22.5) | 8/69 (11.6) | 671/1128 (59.5) | 3/162 (1.9) | 57/118 (48.3) | NA |
| Guatemala | 188/2428 (7.7) | NA | NA | 188/520 (36.2) | NA | NA | NA | NA | NA |
Abbreviations: ALL, acute lymphoblastic leukemia; COG, Children’s Oncology Group; Ma-Spore, Malaysia-Singapore ALL Study Group; NA, not applicable; St Jude, St Jude Children’s Research Hospital.
SI conversion factor: To convert leukocytes to cells ×109/L, multiply by 0.001.
a
Criteria for defining racial and ethnic categories are as described in the eMethods in the Supplement.
b
Determined by use of the χ2 test.