Table 1.
Patient characteristics of aGVHD and cGVHD.
| Characteristics | aGVHD (n = 14) | cGVHD (n = 7) |
|---|---|---|
| Age at HSCT, median (range) | 19 (6–54) | 24 (9–59) |
| Age at HSCT, n (%) | ||
| <18 years | 6 (42.9) | 2 (28.6) |
| ⩾18 years | 8 (57.1) | 5 (71.4) |
| Male sex, n (%) | 6 (42.9) | 2 (28.6) |
| Underlying disease, n (%) | ||
| Acute myeloid leukemia | 4 (28.6) | 5 (71.4) |
| Acute lymphoblastic leukemia | 4 (28.6) | 0 (0) |
| Myelodysplastic syndrome | 1 (7.1) | 1 (14.3) |
| Aplastic anemia | 3 (21.4) | 1 (14.3) |
| Fanconi anemia | 2 (14.3) | 0 (0) |
| Graft type, n (%) | ||
| Bone marrow and peripheral blood stem cells | 13 (92.9) | 7 (100) |
| Peripheral blood stem cells | 1 (7.1) | 0 (0) |
| Donor–recipient relationship, n (%) | ||
| Father–child | 8 (57.1) | 4 (57.1) |
| Mother–child | 3 (21.4) | 1 (14.3) |
| Sibling–sibling | 2 (14.3) | 1 (14.3) |
| Child–parent | 1 (7.1) | 1 (14.3) |
| Donor–recipient sex matched, n (%) | ||
| Male to male | 5 (35.7) | 2 (28.6) |
| Male to female | 6 (42.9) | 3 (42.8) |
| Female to male | 1 (7.1) | 0 (0) |
| Female to female | 2 (14.3) | 2 (28.6) |
| Number of HLA-A, HLA-B, and HLA-DR mismatches, n (%) | ||
| 1 | 0 (0) | 0 (0) |
| 2 | 2 (14.3) | 0 (0) |
| 3 | 12 (85.7) | 7 (100) |
| Donor–recipient blood type matched, n (%) a | ||
| Matched | 5 (35.7) | 6 (85.7) |
| Major mismatched | 5 (35.7) | 1 (14.3) |
| Minor mismatched | 4 (28.6) | 0 (0) |
| Major and minor mismatched | 0 (0) | 0 (0) |
aGVHD, acute graft-versus-host disease; cGVHD, chronic graft-versus-host disease; HLA, human leukocyte antigen; HSCT, hematopoietic stem cell transplantation.
Minor ABO mismatched indicated that donor possessed isohemagglutinins against recipient red cells, including the following blood group combinations: O (donor) into A, B, or AB (recipient), and A or B (donor) into AB (recipient). Major ABO mismatched indicated that recipient possessed isohemagglutinins against donor red cells, including the following blood group combinations: A, B, or AB (donor) into O (recipient), and AB (donor) into A or B (recipient). Major–minor mismatched indicated that both donor and recipient possessed isohemagglutinins to each other; A into B and vice versa.