. 2022 Jan 14;11:821785. doi: 10.3389/fonc.2021.821785

Table 3.

Meta-analyses assessing local anesthetics impact on cancer prognosis.

Cancer	Patients	Design	Cancer prognosis outcome	Ref
Solid tumors	14 studies (47 000 patients)	Control group: general anesthesia	Epidural anesthesia improved overall survival (p=0.013).	(15)
Solid tumors	14 studies (47 000 patients)	Studied group: epidural anesthesia with or without general anesthesia	Epidural anesthesia improved overall survival (p=0.013).	(15)
Solid tumors	10 studies (3254 patients)	Control group: general anesthesia	Combined general-epidural anesthesia was associated with decreased recurrence (p=0.027) and metastasis rate (p=0.035) within the subgroup of prostate cancer patients and the subgroup with follow-up less than or equal to 2 years	(16)
Solid tumors	10 studies (3254 patients)	Studied group: combined general-epidural anesthesia		(16)
Solid tumors	20 studies (NA)	Control group: general anesthesia	Perioperative regional anesthesia associated with improved overall survival ([HR] = 0.84, 95% CI, 0.75-0.94; I ² =41%)	(17)
Solid tumors	20 studies (NA)	Studied group: perioperative regional anesthesia		(17)
Solid tumors	21 studies (51 620 patients)	Control group: general anesthesia	Neuroaxial anesthesia improved overall survival (p=0.026) and recurrence-free survival (p=0.047)	(18)
Solid tumors	21 studies (51 620 patients)	Studied group: neuroaxial anesthesia combined with or without general anesthesia		(18)