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. 2022 Jan 26;10(1):e002643. doi: 10.1136/bmjdrc-2021-002643

Figure 3.

Figure 3

Association between intestinal alkaline phosphatase deficiency (IAPD) and incidence of type 2 diabetes mellitus (T2DM) stratified by gender and age. A prospective cohort of healthy participants without diabetes (n=574, 30–60 years old) were followed up for 5 years. Based on baseline and follow-up IAP values, the participants were classified as having ‘persistent no IAPD’ (intestinal alkaline phosphatase (IAP) level: always ≥65 U/g stool), ‘persistent IAPD’ (IAP level: always <65 U/g stool), ‘incident IAPD’ (IAP level: decreased from ≥65 U/g stool to <65 U/g stool), or ‘remittent IAPD’ (IAP level: increased from <65 U/g U/g stool to ≥65 U/g stool). Post-hoc statistical power analyses revealed adequacy of power (conventionally, >80% power at α=0.05) for different comparative groups (‘persistent no IAPD’ vs ‘incident IAPD’: 98.6%; ‘persistent no IAPD’ vs ‘persistent IAPD’: 99.4%; ‘persistent no IAPD’ vs ‘remittent IAPD’: 90.0%), validating the adequacy of sample size for each group as calculated by an online program (http://clincalc.com/Stats/Power.aspx). Data are unadjusted relative risk (RR) and 95% CI.