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. Author manuscript; available in PMC: 2022 Jan 28.
Published in final edited form as: Gastroenterology. 2020 Feb 4;158(6):1650–1666.e15. doi: 10.1053/j.gastro.2020.01.046

Figure 2.

Figure 2.

Inducible Kras activation via tetON system causes gastric metaplasia and dysplasia

(A)Schema of Tff1-Cre; or Tff2-Cre;R26-rtTA;TetO-KrasG12D-IRES-TdTomato mice. (B)Expression sites of Tff1-Cre, Tff2-Cre, and Mist1-CreERT constructs in corpus glands. (C)Corpus images of Tff1-Cre; or Tff2-Cre;R26-rtTA;TetO-KrasG12D-IRES-TdTomato mice treated with doxycycline for 14 days. First row, H&E; second row, Alcian blue; third row, Tomato(red) and Ki67(green); fourth row, CD44v9(red) and GSII(green); fifth row, GIF(red) and GSII(green) staining. (D)Gene constructs and images of Mist1-CreERT;LSL-KrasG12D;R26-TdTomato mice 42 days after tamoxifen induction shown in the same order as in (C). Bars=50μm.