Table 3.

Genetic loci with the top 10 mean saliency scores at the high performance p value threshold of each ethnicity

Chr.	SNP	Position	Closest gene	Minor/major allele	MAF (%)	OR	95% CI	P value	Mean saliency score
Based on Japanese GWAS
4	rs4611994	111 711 041	PITX2*	T/C	47.64	0.42	0.37 to 0.47	1.29×10−47	1.000
4	rs17042171	111 708 287	PITX2*	C/A	47.66	0.42	0.37 to 0.47	1.20×10−47	0.711
4	rs6843082	111 718 067	PITX2*	A/G	27.21	0.32	0.27 to 0.37	8.06×10−45	0.708
1	rs3737883	203 034 906	PPFIA4*	G/A	31.75	0.67	0.59 to 0.75	1.22×10−10	0.498
4	rs6852021	111 744 112	PITX2*	A/G	49.58	0.79	0.71 to 0.88	1.37×10−5	0.474
1	rs11579055	203 031 315	PPFIA4*	T/G	32.26	0.67	0.59 to 0.76	1.54×10−10	0.434
4	rs723364	111 724 471	PITX2*	G/C	20.32	0.82	0.71 to 0.95	0.006	0.421
4	rs17042144	111 689 666	PITX2*	C/T	42.31	2.01	1.80 to 2.24	1.40×10−34	0.403
1	rs6694477	203 035 365	PPFIA4*	G/A	21.05	0.64	0.55 to 0.74	1.53×10−9	0.386
20	rs11696871	62 387 417	ZBTB46	A/G	48.64	0.94	0.84 to 1.04	0.242	0.385
Based on European GWAS
4	rs4611994	111 711 041	PITX2*	T/C	47.64	0.42	0.37 to 0.47	1.29×10−47	1.000
4	rs17042171	111 708 287	PITX2*	C/A	47.66	0.42	0.37 to 0.47	1.20×10−47	0.740
4	rs6843082	111 718 067	PITX2*	A/G	27.21	0.32	0.27 to 0.37	8.06×10−45	0.716
1	rs11579055	203 031 315	PPFIA4*	T/G	32.26	0.67	0.59 to 0.76	1.54×10−10	0.488
1	rs3737883	203 034 906	PPFIA4*	G/A	31.75	0.67	0.59 to 0.75	1.22×10−10	0.486
22	rs464385	18 571 008	TUBA8*	A/G	43.12	1.01	0.91 to 1.13	0.824	0.485
4	rs17042144	111 689 666	PITX2*	C/T	42.31	2.01	1.80 to 2.24	1.40×10−34	0.457
22	rs361594	18 577 338	TUBA8*	T/C	48.19	0.91	0.82 to 1.02	0.105	0.440
1	rs6694477	203 035 365	PPFIA4*	G/A	21.05	0.64	0.55 to 0.74	1.53×10−9	0.401
4	rs3866838	111 753 815	PITX2*	T/C	17.75	0.85	0.73 to 0.98	0.025	0.399
Based on multi-ethnic GWAS
4	rs4611994	111 711 041	PITX2*	T/C	47.64	0.42	0.37 to 0.47	1.29×10−47	1.000
4	rs6843082	111 718 067	PITX2*	A/G	27.21	0.32	0.27 to 0.37	8.06×10−45	0.827
1	rs3737883	203 034 906	PPFIA4*	G/A	31.75	0.67	0.59 to 0.75	1.22×10−10	0.634
4	rs17042171	111 708 287	PITX2*	C/A	47.66	0.42	0.37 to 0.47	1.20×10−47	0.540
4	rs2067518	174 612 666	HAND2*	G/A	45.85	0.73	0.65 to 0.81	1.38×10−8	0.531
1	rs11579055	203 031 315	PPFIA4*	T/G	32.26	0.67	0.59 to 0.76	1.54×10−10	0.527
1	rs6694477	203 035 365	PPFIA4*	G/A	21.05	0.64	0.55 to 0.74	1.53×10−9	0.515
4	rs12507756	174 609 772	HAND2*	C/T	45.78	0.73	0.65 to 0.81	2.00×10−8	0.459
1	rs6689393	154 426 097	KCNN3*	A/G	45.99	1.07	0.96 to 1.19	0.199	0.458
1	rs535709	170 120 831	METTL11B*	C/T	12.92	1.04	0.88 to 1.22	0.648	0.430

*Genes are previously proven AF associated loci.

AF, atrial fibrillation; Chr., chromosome; GWAS, Genome-Wide Association Study; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.