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. 2022 Jan 24;10(1):e003024. doi: 10.1136/jitc-2021-003024

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Illustration of TFS assessment and OS curve partitioning. TFS estimates for (B) NIVO plus IPI, (C) nivolumab, and (D) ipilimumab in patients with melanoma in CheckMate 067 and 069. Data labels represent the mean number of months and the percentage of time in a treatment state during the 60-month period.8 9 Areas are restricted mean times. ^aTime after cessation of protocol therapy without toxicity before initiation of subsequent systemic anticancer therapy or death. ^bTime after cessation of protocol therapy with toxicity while treatment-free. Permissions to use figures: licensed under the Creative Commons Attribution V.4.0 License (CC BY 4.0) (https://creativecommonsorg/licenses/by/40/). IPI, ipilimumab; NIVO, nivolumab; OS, overall survival; TFS, treatment-free survival.