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. 2021 Nov 23;122(2):2017–2291. doi: 10.1021/acs.chemrev.1c00374

Figure 12.

Figure 12

Ru-catalyzed photo-cross-linking reaction of tyrosine-containing peptide hydrogels. (A) Structure of FmocFFGGGY and schematic illustration of hydrogelation and Ru-catalyzed photo-cross-linking of hydrogel. (B) Mechanism of photomediated cross-linking reaction of tyrosine to form the cross-linked dityrosine adduct. (C) UV–vis spectra experiments showing evidence of the formation of peptide dimer through a dityrosine bond. (D, E) TEM images of uncross-linked and cross-linked hydrogels, suggesting increased entanglement of the peptide fibrils upon photo-cross-linking. Reproduced with permission from ref (1068). Copyright 2013 ACS Publications.