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. 2021 Dec 22;8(1):43–50. doi: 10.1021/acscentsci.1c00972

Table 3. Scale-up Production of Three Pharmaceutical Scaffolds Including Letrozole Precursor by Using 16N-PMR Assembly and Comparative Synthetic Performance of SMR and 4N-PMR.

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microreactor yield of 2b [%]a output of 2b [mg min–1] yield of 2h [%]b output of 2h [mg min–1] yield of 2j [%]c output of 2j [mg min–1]
SMR 86 131.2 98 137.7 86 70.8
4N-PMR 85 518.8 97 545.3 84 276.5
16N-PMR 81 1971.0 92 2068.9 80 1053.2
a

Yield of isolated product.

b

Determined by 1H NMR spectroscopy using 1,3,5-trimethoxybenzene as an internal standard.

c

The yield was determined by GC.