Table 2.

Incidence rates and hazard ratios according to DAA treatment exposure for all-cause mortality, liver-related mortality, non-liver-related mortality, and liver transplant in all 559 patients with history of decompensated cirrhosis

	Not exposed to DAA (N = 76)		Exposed to DAA (N = 483)		Unadjusted	Multivariate analysis	IPTW
	n/pyr	Incidence/100pyrs (95% CI)	n/pyr	Incidence/100pyrs (95% CI)	HR [95% CI]	HR [95% CI]	HR [95% CI]
HCC (N = 92)	20/325	6.1 (3.8–9.5)	72/1374	5.2 (4.1–6.6)	0.81 (0.47–1.38)	0.80 (0.44–1.45)	0.85 (0.50–1.47)
All cause-mortality (N = 119)	39/341	11.4 (8.1–15.6)	80/1494	5.3 (4.2–6.7)	0.40 (0.24–0.65)*	0.45 (0.24–0.84)*	0.42 (0.25–0.68)*
Liver related mortality (N = 74)	22/341	6.4 (4.0–9.8)	52/1494	3.5 (2.6–4.6)	0.50 (0.24–1.05)	0.89 (0.358–2.26)	0.60 (0.28–1.29)
Non-liver related mortality (N = 35)	11/341	3.2 (1.6–5.8)	24/1494	1.6 (1.0–2.4)	0.35 (0.16–0.75)*	0.26 (0.08–0.82)*	0.34 (0.16–0.74)*
Liver transplant (N = 36)	10/329	3.0 (1.5–5.6)	26/1414	1.8 (1.2–2.7)	0.51 (0.20–1.31)	0.53 (0.14–1.96)	0.54 (0.21–1.41)

*Significant analysis associations at the p < 0.05 level