Table 4.

Hazard ratios for hepatocellular carcinoma, all-cause mortality, liver-related mortality, non-liver-related mortality, and liver transplant. 483 DAA-exposed versus 76 unexposed patients are compared according to exposure period and virological response status

	On treatment N = 483		SVR N = 391		No SVR N = 53		Unknown SVR N = 39
	Univariable HR (95% CI)	Multivariable-adjusted HR (95% CI)	Univariable HR (95% CI)	Multivariable-adjusted HR (95% CI)	Univariable HR (95% CI)	Multivariable-adjusted HR (95% CI)	Univariable HR (95% CI)	Multivariable-adjusted HR (95% CI)
Hepatocellular carcinoma	0.76 (0.45–1.29)	0.77 (0.43–1.36)	0.49 (0.28–0.85)*	0.52 (0.29–0.93)*	1.53 (0.74–3.18)	1.16 (0.52–2.60)	0.50 (0.15–1.71)	0.50 (0.15–1.73)
All-cause mortality	0.35 (0.21–0.57)*	0.47 (0.25–0.86)*	0.22 (0.13–0.37)*	0.29 (0.15–0.54)*	0.38 (0.13–1.09)	0.66 (0.19–2.28)	0.47 (0.17–1.33)	0.94 (0.28–3.11)
Liver-related mortality	0.44 (0.21–0.91)*	0.61 (0.25–1.47)	0.29 (0.14–0.62)*	0.40 (0.17–0.96)*	0.42 (0.09–1.98)	0.77 (0.15–4.10)	0.55 (0.12–2.48)	0.68 (0.14–3.43)
Non-liver-related mortality	0.30 (0.14–0.66)*	0.26 (0.09–0.76)*	0.20 (0.09–0.47)*	0.17 (0.06–0.49)*	0.24 (0.03–1.73)	0.18 (0.02–1.28)	0.57 (0.13–2.50)	1.38 (0.19–10.10)
Liver transplant	0.50 (0.20–1.25)	0.32 (0.09–1.08)	0.23 (0.08–0.67)*	0.17 (0.05–0.54)*	0.51 (0.06–4.09)	0.36 (0.07–1.82)	ND	ND

*Significant analysis associations at the p < 0.05 level. ND: Not performed due to insufficient number of events