Table 1.
Clinical and demographic characteristics of 167 patients included in study cohort
| Euploid miscarriage | Aneuploid miscarriage | Control (term pregnancy) | p value | |
|---|---|---|---|---|
| Number of women | 54 | 39 | 74 | |
|
Maternal age, years Median (range) |
32 (17–46) | 36 (27–45) | 32 (20–44) | †0.0044 |
|
BMI (kg/m2) Median (range) |
25.1 (17.7–35) | 24.4 (18.7–39.4) | 24.5 (18–38.4) | †0.205 |
| Smokers (%) | 7 (13) | 2 (5.1) | 3 (3.7) | ††0.189 |
| Ethnicity (%) | ||||
| White | 30 (56) | 24 (62) | 54 (73) | †††0.1271 |
| Asian | 15 (28) | 11 (28) | 10 (13.5) | |
| Black | 7 (13) | 4 (10) | 10 (13.5) | |
| Mixed | 2 (3) | 0 (0) | 0 (0) | |
| Previous miscarriage (%) | ||||
| 0 | 30(55.6) | 22 (56.4) | 31 (42) | ††††0.0084 |
| 1 | 9(16.7) | 6 (15.3) | 29 (39) | |
| 2 | 9 (16.7) | 7 (18) | 10 (14) | |
| ≥ 3 | 6 (11) | 4 (10.3) | 4 (5) | |
| Gestational age group at sampling (%) | ||||
| 5–8 weeks | 14 (26) | 14 (36) | 7 (10) | †††0.0083 |
| 8–10 weeks | 24 (44) | 19 (49) | 41(55) | |
| 10–14 weeks | 16 (30) | 6 (15) | 26 (35) | |
| Bleeding score | ||||
| 0 | 28 | 24 | 65 | †††0.0002 |
| 1 | 13 | 11 | 9 | |
| 2 | 8 | 2 | 0 | |
| 3 | 3 | 2 | 0 | |
| 4 | 2 | 0 | 0 | |
| Status at sampling | ||||
| Missed | 40 | 35 | †††0.1 | |
| Incomplete | 4 | 0 | ||
| Viable | 10 | 4 | ||
†Kruskal-Wallis test
††Fisher’s exact (two-tailed)
†††Chi-squared
††††Chi-squared combining euploid and aneuploid miscarriages and comparing with viable term pregnancies