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. 2022 Jan 28;19:8. doi: 10.1186/s12987-022-00304-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cross-sectional average tracer concentration over 3-h and regression plots to compare numerical simulation with in vitro model at different injection locations a Lumbar puncture, b Cisterna magna and c Intracerebroventricular injection. a1, b1, c1 Spatial temporal plot for cross-sectional average tracer concentration for CFD at LP, CM and ICV, respectively. a2, b2, c2 Spatial temporal plot for cross-sectional average tracer concentration for in vitro model at LP, CM and ICV, respectively. a3, b3, c3 the linear correlation plots for agreement of in vitro and numerical simulation results for spatial–temporal cross-sectional average tracer concentration over 3-h at LP, CM and ICV, respectively. The linear regression is shown in black dashed line and the idea line is shown in black solid line. a4, b4, c4 Bland–Altman plots for agreement of in vitro and numerical simulation results for spatial–temporal cross-sectional average tracer concentration over 3-h at LP, CM and ICV, respectively. The limit of agreement (95% confidence intervals) lines are shown in dashed lines and the mean value of differences between CFD and in vitro is shown in solid blue line