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. 2022 Jan 28;26:29. doi: 10.1186/s13054-022-03893-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PMN transcriptomics revealed significant changes in glycolysis and mTOR/HIF-1α signaling pathway. a Heat map of DEGs identified by RNA-seq between patients with sepsis and healthy controls (P < 0.05). b Differential expression levels of glycolysis-associated genes in patients with sepsis versus those in healthy controls. c Histogram of KEGG enrichment analysis showing 22 significantly enriched pathways in patients with sepsis. KEGG ontology assignments were used to classify functional annotations of identified genes to elucidate their biological functions