Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 7;23(3):205. doi: 10.3892/etm.2022.11128

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Effects of WG and DOX on apoptosis related signaling pathways in rat heart. (A) WG effectively improved the increased mRNA expression of Cyp D, VDAC1 and ANT1 in DOX rats, (B) the decreased expression of mitochondrial cytochrome c protein and (D) the increased the expression of cytoplasmic cytochrome c protein, the increased expression of cleaved-caspase-9/3 and the decreased expression of pro-caspase-3. (C and E) Semi quantitative analysis. The expression level of mitochondrial Cyt C specific protein was normalized to COX IV. All values are the mean ± SD. ^*P<0.05, ^**P<0.01 vs. CON; ^#P>0.05, ^##P>0.01 vs. DOX. WG, wogonin; DOX, doxorubicin; VDAC1, voltage-dependent anion-selective channel 1; Cyp D, cyclophilin D; ANT1, adenine nucleotide transporter 1; Cyt C, cytochrome c.