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. 2022 Jan 7;23(3):205. doi: 10.3892/etm.2022.11128

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Copyright: © Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of WG and DOX on apoptosis related signaling pathways in cardiomyocytes. (A) As in the animal models, WG effectively improved the increased mRNA expression of Cyp D, VDAC1 and ANT1 in DOX rats, (B) the decreased expression of mitochondrial cytochrome c protein and (D) the increased the expression of cytoplasmic cytochrome c protein and the increased expression of cleaved-caspase-9/3 and the decreased expression of pre-caspase-3. (C and E) semi-quantitative analysis. All values are the mean ± SD. ^*P<0.05, ^**P<0.01 vs. CON, ^#P>0.05, ^##P>0.01 vs. DOX. WG, wogonin; DOX, doxorubicin; VDAC1, voltage-dependent anion-selective channel 1; Cyp D, cyclophilin D; ANT1, adenine nucleotide transporter 1.