Fig. 2.

Chronic kidney disease promotes cardiac remodelling. A Cardiac remodelling measured by echography in sham and 5/6 nephrectomy (Nx) mice showing heart weight (HW), left ventricular mass (LVM), ejection fraction, fractional shortening, and diastolic/systolic left ventricular posterior wall (LVPW) thickness, intraventricular septum (IVS) thickness, and left ventricular internal diameter (LVID). Parameters are normalised to tibia length. B Intracarotid mean, systolic (SBP) and diastolic (DBP) blood pressure expressed in mmHg for sham and 5/6 Nx mice (* P < 0.05, ** P < 0.01). C Plasma levels of cardiac troponin I in ng/mL for sham and 5/6 Nx mice. D Fold change from sham in expression of extracellular matrix and cardiac injury genes in hearts of 5/6 nephrectomised mice (12 weeks). Grey line represents no change from sham (* P < 0.05, ** P < 0.01). E Cardiomyocyte cell areas and geodesic diameters (length of the shortest path between two furthest points) in hearts of sham and 5/6 Nx mice and representative A488-WGA staining images (scale bar = 50 μm). Each point represents the mean of at least 300 to 3000 cardiomyocytes per animal (** P < 0.01)