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. 2022 Jan 28;23:47. doi: 10.1186/s12882-021-02593-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CCR2^−/− mice do not show increased numbers of cardiac macrophages and cardiac dysfunction during chronic kidney disease. A F4/80⁺MHCII^hi and F4/80⁺MHCII^lo resident macrophage numbers per mg of heart tissue in vehicle and folate treated (wild-type) WT and CCR2^−/− mice (* P < 0.05). B Ejection fraction (left) and fractional shortening (right) measured by echography in vehicle and folate treated WT and CCR2^−/− mice (* P < 0.05). C Cardiac levels of troponin I in ng/mL in vehicle and folate treated WT and CCR2^−/− mice. D Intracarotid mean, systolic (SBP) and diastolic (DBP) blood pressure expressed in mmHg in vehicle and folate treated WT and CCR2^−/− mice. E Fold change from vehicle in expression of extracellular matrix and cardiac injury genes in folate treated WT and CCR2^−/− mice. Grey line represents no change from control (* P < 0.05, ** P < 0.01). F Cardiomyocyte cell areas and geodesic diameters (length of the shortest path between two furthest points) in hearts of vehicle and folate treated WT and CCR2^−/− mice. Each point represents the mean of at least 1000 to 3000 cardiomyocytes per animal (** P < 0.01, *** P < 0.001)