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. 2022 Jan 28;23:85. doi: 10.1186/s12864-021-08269-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Visualizing the proportion of NDE/NIE versus visit code per QT-PAD outcome. Using the results of the mediation analysis, we plotted the proportion of the natural direct effect (NDE) versus the natural indirect effect (NIE) over time per outcome. Outcomes with a significant NDE and NIE have been marked with a red ‘X‘; the horizontal color bar represents the SNPs for which the mediation effect has been measured. Although the primary findings are focused on rs5011804, the mediation effect coefficients for three other AD SNPs are shown here for reference