Table 1.
Mann-Whitney U Test P Values for Fig. 2(a-d)
| Visit (Dosage) | CDRSB P | FAQ P | ADAS13 P | Fusiform P |
|---|---|---|---|---|
| bl (0 vs 1) | 3.59e-6 | 1.37e-5 | 1.08e-4 | 6.56e-2 |
| bl (0 vs 2) | 2.81e-9 | 1.95e-8 | 3.01e-8 | 4.19e-3 |
| bl (1 vs 2) | 2.22e-3 | 2.63e-3 | 1.29e-3 | 2.47e-2 |
| m06 (0 vs 1) | 8.60e-6 | 1.23e-6 | 3.67e-5 | 2.11e-1 |
| m06 (0 vs 2) | 1.58e-11 | 1.09e-10 | 2.03e-10 | 4.39e-4 |
| m06 (1 vs 2) | 2.44e-4 | 5.69e-4 | 1.56e-4 | 2.37e-3 |
| m12 (0 vs 1) | 1.44e-7 | 6.34e-7 | 5.62e-6 | 1.71e-1 |
| m12 (0 vs 2) | 3.79e-10 | 7.35e-10 | 1.63e-11 | 7.55e-5 |
| m12 (1 vs 2) | 2.15e-3 | 2.30e-3 | 6.14e-5 | 4.19e-4 |
| m24 (0 vs 1) | 5.19e-4 | 3.26e-4 | 5.16e-3 | 2.52e-1 |
| m24 (0 vs 2) | 7.50e-8 | 1.13e-7 | 3.21e-7 | 5.12e-4 |
| m24 (1 vs 2) | 1.29e-3 | 1.87e-3 | 1.03e-3 | 2.94e-5 |
The index/leftmost column of the table represents the two specific allelic dosage means being compared at a specific time point. For example, in the first row, the differences in the average baseline levels for each of the four listed phenotypes (CDRSB, FAQ, ADAS13, and FreeSurfer Fusiform) are compared between individuals with 0 copies and 1 copy of the minor allele of the SNP rs5011804. The visit codes have been abbreviated as follows: bl represents baseline measures, m06 represents measures at the month 6 visit, m12 represents measures at the month 12 visit, and m24 represents measures at the month 24 visits. A Mann–Whitney U test p value threshold was determined using the Bonferroni correction, setting a threshold of 1.04∗10−3