Table 3. Novel pharmacogenomics variants in Saudi population.

Gene	Variant	Variant type	Minor allele frequency, SA (%)
CYP2C19	NM_000769.4:c.914C>A:p.Thr305Asn	missense	0.00420557
CYP2C19	NM_000769.4:c.332-1G>A	splice acceptor	0.00841114
CYP2C19	NM_000769.4:c.482-2A>G	splice acceptor	0.00841114
CYP2C19	NM_000769.4:c.1034T>C:p.Met345Thr	missense	0.01682227
CYP2C19	NM_000769.4:c.1071A>C:p.Arg357Ser	missense	0.00841114
CYP2C9	NM_000771.4:c.1023C>G:p.Asp341Glu	missense	0.00420557
CYP2C9	NM_000771.4:c.893G>C:p.Gly298Ala	missense	0.01261670
CYP2C9	NM_000771.4:c.961+1G>A	splice donor	0.00841114
CYP2C9	NM_000771.4:c.1061A>G:p.Glu354Gly	missense	0.00420557
CYP2C9	NM_000771.4:c.1198G>T:p.Glu400Ter	stop gained	0.01682227
CYP2C9	NM_000771.4:c.1243G>T:p.Glu415Ter	stop gained	0.00420557
CYP3A5	NM_000777.5:c.1205A>G:p.His402Arg	missense	0.00420557
CYP3A5	NM_000777.5:c.1120G>A:p.Glu374Lys	missense	0.00420557
CYP3A5	NM_000777.5:c.1067T>C:p.Leu356Pro	missense	0.00420557
CYP3A5	NM_000777.5:c.1063T>C:p.Tyr355His	missense	0.00420557
CYP3A5	NM_000777.5:c.957T>A:p.Tyr319Ter	stop gained	0.01682227
CYP3A5	NM_000777.5:c.931A>G:p.Ser311Gly	missense	0.00420557
CYP3A5	NM_000777.5:c.409T>C:p.Phe137Leu	missense	0.00420557
CYP3A5	NM_000777.5:c.219-2A>G	splice acceptor	0.00420557
CYP4F2	NM_001082.5:c.1288A>T:p.Asn430Tyr	missense	0.02102784
CYP4F2	NM_001082.5:c.1231G>C:p.Gly411Arg	missense	0.00420557
CYP4F2	NM_001082.5:c.985G>A:p.Gly329Ser	missense	0.00420557
CYP4F2	NM_001082.5:c.889G>T:p.Asp297Tyr	missense	0.00841114
DPYD	NM_000110.4:c.2836delG:p.Ala946LeufsTer2	frameshift	0.00841114
DPYD	NM_000110.4:c.1526C>G:p.Ser509Ter	stop gained	0.00420557
DPYD	NM_000110.4:c.958+1G>A	splice donor	0.00841114
DPYD	NM_000110.4:c.390T>A:p.Cys130Ter	stop gained	0.00420557
DPYD	NM_000110.4:c.2912T>C:p.Ile971Thr	missense	0.05467239
DPYD	NM_000110.4:c.2310C>G:p.Ile770Met	missense	0.00420557
DPYD	NM_000110.4:c.2137A>C:p.Asn713His	missense	0.00420557
DPYD	NM_000110.4:c.2083T>G:p.Cys695Gly	missense	0.00420557
DPYD	NM_000110.4:c.1804C>A:p.Pro602Thr	missense	0.00420557
DPYD	NM_000110.4:c.1679T>C:p.Ile560Thr	missense	0.00420557
DPYD	NM_000110.4:c.1657C>T:p.Pro553Ser	missense	0.00420557
DPYD	NM_000110.4:c.1591G>A:p.Val531Met	missense	0.00420557
DPYD	NM_000110.4:c.1405A>G:p.Met469Val	missense	0.00420557
DPYD	NM_000110.4:c.1309G>A:p.Ala437Thr	missense	0.00841114
DPYD	NM_000110.4:c.1076T>C:p.Val359Ala	missense	0.00420557
DPYD	NM_000110.4:c.574C>T:p.Leu192Phe	missense	0.00420557
DPYD	NM_000110.4:c.431C>T:p.Ala144Val	missense	0.01682227
DPYD	NM_000110.4:c.217C>T:p.Leu73Phe	missense	0.00420557
DPYD	NM_000110.4:c.194C>A:p.Thr65Lys	missense	0.00420557
TPMT	NM_000367.5:c.581G>A:p.Gly194Asp	missense	0.00841114
TPMT	NM_000367.5:c.454A>G:p.Arg152Gly	missense	0.01682227
TPMT	NM_000367.5:c.202C>A:p.Pro68Thr	missense	0.00420557
VKORC1	NM_024006.6:c.404G>A:p.Cys135Tyr	missense	0.01261670