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. 2020 Nov;9(11):6652–6659. doi: 10.21037/tcr-20-516

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2020 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Immunohistochemical and transcript analysis of TM9SF4 expression in colon tissues. (A) preneoplastic lesion (hyperplastic polyps and sessile serrated polyps); (B) tubular adenoma; (C) colorectal adenocarcinoma. Magnification ×200. (D) Two-way ANOVA followed by Bonferroni post test analysis of TM9SF4 IHC score values of colon cancer samples at different stages of disease. **, P<0.01, ***, P<0.001 (Figure S1A). 0–1 = negative/borderline; 1 = weakly expressed; 2 = expressed; 3 = strongly positive. CTR, Healthy colon mucosa; HP, Hyperplastic polyps; SSP, sessile serrated polyps; TVA, tubular villous adenoma; CRC, colorectal cancer.