Table S1. Clinicopathological characteristics of the included 25 studies.
| Authors | Group | No. | Tumor size ± SD (cm) | Pain | Bleeding | Cardiopulmonary disease | Differentiation | SRCC | Mucinous | Lauren type | Borrmann classification | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Well | Poor | Intestinal | Diffuse | Mixed | I | II | III | IV | ||||||||||
| Song et al. (4) | YG | 112 | ≤6 n=70; >6 n=42 | – | – | – | 6 | 106 | – | – | – | – | – | – | – | – | – | |
| OG | 358 | ≤6 n=239; >6 n=119 | – | – | – | 83 | 275 | – | – | – | – | – | – | – | – | – | ||
| Cormedi et al. (5) | YG | 71 | – | – | – | – | – | – | – | – | 3 | 57 | 3 | – | – | – | – | |
| OG | 223 | – | – | – | – | – | – | – | – | 78 | 74 | 14 | – | – | – | – | ||
| Tavares et al. (8) | YG | 23 | – | 12 | 3 | – | 4 | 12 | – | – | 8 | 15 | 0 | – | – | – | – | |
| OG | 360 | – | 160 | 100 | – | 56 | 89 | – | – | 255 | 105 | 0 | – | – | – | – | ||
| Guan et al. (9) | YG | 1,369 | 5.00±3.00 | – | – | – | 31 | 916 | 558 | 25 | 668 | 652 | – | – | – | – | – | |
| OG | 46,521 | 4.00±1.47 | – | – | – | 2493 | 22,616 | 5756 | 990 | 37,799 | 7,021 | – | – | – | – | – | ||
| Isobe et al. (10) | YG | 169 | – | – | – | – | – | 66 | 75 | 4 | – | – | – | – | – | – | – | |
| OG | 3,649 | – | – | – | – | – | 943 | 600 | 82 | – | – | – | – | – | – | – | ||
| Kim et al. (11) | YG | 137 | 5.07±3.23 | – | – | – | – | – | 25 | 4 | – | – | – | 5 | 13 | 93 | 26 | |
| OG | 194 | 5.16±3.45 | – | – | – | – | – | 6 | 10 | – | – | – | 10 | 43 | 128 | 13 | ||
| Kunisaki et al. (12) | YG | 131 | <5 n=76; ≥5 n=55 | – | – | – | 30 | 101 | – | – | – | – | – | – | – | – | – | |
| OG | 918 | <5 n=536; ≥5 n=382 | – | – | – | 479 | 439 | – | – | – | – | – | – | – | – | – | ||
| Liu et al. (13) | YG | 198 | – | – | – | 0 | 7 | 164 | – | – | – | – | – | – | – | – | – | |
| OG | 1,096 | – | – | – | 29 | 123 | 587 | – | – | – | – | – | – | – | – | – | ||
| Okamoto et al. (14) | YG | 34 | – | – | – | – | – | 22 | 2 | 0 | – | – | – | 0/20 | 0 | 12 | 4 | |
| OG | 132 | – | – | – | – | – | 51 | 1 | 5 | – | – | – | 3/85 | 25 | 34 | 14 | ||
| Takatsu et al. (15) | YG | 136 | – | – | – | – | 13 | 123 | – | – | – | – | – | – | – | – | – | |
| OG | 1,435 | – | – | – | – | 662 | 773 | – | – | – | – | – | – | – | – | – | ||
| Tekesin et al. (16) | YG | 92 | – | 22 | 6 | – | – | – | – | – | 39 | 45 | 7 | – | – | – | – | |
| OG | 774 | – | 191 | 52 | – | – | – | – | – | 526 | 220 | 21 | – | – | – | – | ||
| Wang et al. (17) | YG | 21 | <5 n=13; ≥5 n=8 | – | – | – | 4 | 10 | 4 | 1 | – | – | – | 1 | 6 | 12 | 2 | |
| OG | 36 | <5 n=23; ≥5 n=13 | – | – | – | 10 | 4 | 2 | 5 | – | – | – | 2 | 13 | 19 | 1 | ||
| Hsieh et al. (18) | YG | 115 | 4.80±3.50 | – | – | – | 17 | 98 | – | – | 17 | 64 | 13 | – | – | – | – | |
| OG | 1,009 | 4.50±3.00 | – | – | – | 453 | 556 | – | – | 491 | 279 | 103 | – | – | – | – | ||
| Ma et al. (19) | YG | 125 | – | – | – | – | 3 | 111 | – | – | – | – | – | – | – | – | – | |
| OG | 1,752 | – | – | – | – | 93 | 1,228 | – | – | – | – | – | – | – | – | – | ||
| Mitsudomi et al. (20) | YG | 128 | – | 48 | 6 | 3 | 5 | 94 | – | – | – | – | – | 2 | 11 | 28 | 20 | |
| OG | 1,275 | – | 20 | 3 | 14 | 600 | 449 | – | – | – | – | – | 20 | 175 | 347 | 106 | ||
| Kulig et al. (21) | YG | 214 | – | 90 | 12 | 2 | – | – | – | – | 42 | 80 | 18 | – | – | – | – | |
| OG | 3,217 | – | 1831 | 186 | 293 | – | – | – | – | 1,106 | 623 | 207 | – | – | – | – | ||
| Bani-Hani et al. (22) | YG | 17 | – | 12 | 2 | – | – | 8 | – | – | 6 | 11 | – | – | – | – | – | |
| OG | 159 | – | 109 | 23 | – | – | 41 | – | – | 121 | 18 | – | – | – | – | – | ||
| Kim et al. (23) | YG | 175 | – | – | – | – | 42 | 133 | – | – | – | – | – | – | – | – | – | |
| OG | 1,124 | – | – | – | – | 608 | 516 | – | – | – | – | – | – | – | – | – | ||
| Lai et al. (24) | YG | 883 | ≤4 n=586; >4 n=288 | – | – | – | 135 | 711 | – | – | – | – | – | 10 | 114 | 297 | 75 | |
| OG | 6,071 | ≤4 n=354; >4 n=2,488 | – | – | – | 2,661 | 3,232 | – | – | – | – | – | 665 | 812 | 2,039 | 405 | ||
| Maehara et al. (25) | YG | 174 | 7.10±4.20 | – | – | – | 39 | 135 | – | – | – | – | – | – | – | – | – | |
| OG | 356 | 6.30±3.80 | – | – | – | 225 | 129 | – | – | – | – | – | – | – | – | – | ||
| Silva et al. (26) | YG | 62 | ≤5 n=31; >5 n=27 | – | – | – | – | – | – | – | 15 | 36 | 11 | – | – | – | – | |
| OG | 453 | ≤5 n=179; >5 n=259 | – | – | – | – | – | – | – | 230 | 146 | 77 | – | – | – | – | ||
| Zhou et al. (27) | YG | 152 | – | 73 | 19 | – | – | – | – | – | 14 | 120 | 18 | – | – | – | – | |
| OG | 250 | – | 98 | 11 | – | – | – | – | – | 156 | 73 | 21 | – | – | – | – | ||
| Adachi et al. (28) | YG | 36 | 6 | 23 | – | 0 | – | 33 | – | – | – | – | – | – | – | – | – | |
| OG | 68 | 6.05 | 16 | – | 21 | – | 35 | – | – | – | – | – | – | – | – | – | ||
| Bautista et al. (29) | YG | 46 | – | – | – | 3 | 0 | 37 | – | – | 14 | 32 | – | – | – | – | – | |
| OG | 1,208 | – | – | – | 564 | 40 | 759 | – | – | 754 | 494 | – | – | – | – | – | ||
| Wang et al. (30) | YG | 342 | – | – | – | – | 16 | 258 | 86 | 16 | 64 | 166 | 112 | 18 | 114 | 156 | 54 | |
| OG | 3,588 | – | – | – | – | 172 | 2,244 | 534 | 233 | 790 | 2,049 | 1,027 | 272 | 1,252 | 1,756 | 308 | ||
No., number of patients; Pain, abdominal pain; SRCC, signet ring cell carcinoma; YG, younger group; OG, older group.